PrEP vs. PEP
Two different ways to prevent HIV. Learn what each is, who it’s for, and when to use it.
PrEP
Take control. Prevent HIV.
PrEP (pre-exposure prophylaxis) is a safe and effective medication for people who do not have HIV and want to reduce their risk of getting it.
- For ongoing protection
- A daily pill, or a long-acting injection for eligible patients
- Reduces the risk of getting HIV from sex by about 99% when taken as prescribed
- A good option if you are sexually active and want to stay protected
PEP
Act quickly. Prevent HIV after exposure.
PEP (post-exposure prophylaxis) is emergency medication to prevent HIV after a possible exposure. It must be started as soon as possible, within 72 hours.
- For emergency situations
- Started within 72 hours after a possible exposure
- Taken every day for 28 days
- Helps prevent HIV from establishing in your body
- Not a substitute for PrEP
Key Differences
A quick comparison to help you understand which option may be right for you.
| Feature | PrEP | PEP |
|---|---|---|
| Purpose | Ongoing prevention | Emergency prevention after exposure |
| When to start | Before possible exposure | Within 72 hours after possible exposure |
| How it’s taken | Daily pill, or an injection every few months | Every day for 28 days |
| Who it’s for | People at ongoing risk for HIV | People with a recent possible exposure |
| Effectiveness | Highly effective when taken as prescribed | Effective when started quickly, within 72 hours |
| Ongoing use | Yes | No (short-term, 28 days) |
Who might consider each option?
PrEP may be right for you if you:
- Are sexually active and want to reduce your risk of HIV
- Have multiple partners
- Have a partner with HIV
- Are not always sure of your partner’s HIV status
- Want a proactive, ongoing prevention option
PEP may be right for you if you:
- Had sex without a condom in the last 72 hours
- Think a condom broke or slipped
- Were exposed to a partner with HIV
- Experienced another potential exposure
- Want emergency prevention as soon as possible
Possible HIV exposure in the last 72 hours?
PEP may help prevent HIV, but it must be started quickly. Call us now. If you can’t reach us right away, go to an emergency room or urgent care and ask about PEP.
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